ontinuous pasteurization of high-viscosity matrices, solid suspensions, and non-Newtonian solutions presents critical engineering challenges in the food, dairy, and biotechnology sectors. Achieving target microbiological and enzymatic inactivation ($D$ and $z$ values) without inducing protein thermal denaturation, unwanted Maillard reactions, or premature fouling requires advancing beyond simplified heat transfer models. This technical article examines non-stationary fluid rheology, boundary-layer fouling mitigation, and system design criteria for regenerative thermal recovery reaching up to 90% efficiency—significantly reducing operational expenditures (OPEX) and industrial carbon footprint.